Kallikrein-kinin system as a target for diabetic retinopathy treatment

• Published in: Vestnik oftal'mologii Vol. 128; no. 4; p. 78
• Main Authors: Iarovaia, G A, Neshkova, E A, Blokhina, T B, Kochergin, S A, Vorob'eva, I V, Gigineishvili, D N
• Format: Journal Article
• Language: Russian
• Published: Russia (Federation) 01.07.2012
• Subjects: Capillary Permeability - drug effects; Diabetic Retinopathy - complications; Diabetic Retinopathy - drug therapy; Diabetic Retinopathy - metabolism; Drug Discovery; Forecasting; Humans; Kallikrein-Kinin System - drug effects; Kallikrein-Kinin System - physiology; Macular Edema - etiology; Macular Edema - metabolism; Macular Edema - prevention & control; Molecular Targeted Therapy - trends; Plasma Kallikrein - antagonists & inhibitors; Plasma Kallikrein - metabolism; Renin-Angiotensin System - physiology; Vasopressins - antagonists & inhibitors; Vasopressins - metabolism
• ISSN: 0042-465X

Multifactor etiology of diabetic retinopathy (DR) determines difficulty of understanding of pathogenesis and need of search of effective approaches to study key mechanisms of development of this microvascular complication of diabetes mellitus (DM). Significant achievements of the last years show the contribution of two proteolytic systems into pathogenesis of DR, that control vascular tone and permeability - kallikrein-kinin (KKS) and renin-angiotensin systems (RAS). Among new approaches to DR treatment one of the most appropriate is an influence on KKS by means of inhibiting kallikrein, that leads to reduction of retinal vascular permeability and allows to prevent the development of macula oedema and other consequences of vascular wall damage in DR.