The role of group 3 innate lymphoid cells(ILC3) in the evolution of the immune system: An update

Group 3 innate lymphoid cells (ILC3) are an ILC subset that is characterized by the expression of retinoic acid-related orphan nuclear receptor γt (RORγt) and interleukin 22 (IL-22). This review summarizes the role of ILC3 in coordinating innate immunity and adaptive immunity based on current resear...

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Published inXi bao yu fen zi mian yi xue za zhi Vol. 39; no. 6; p. 558
Main Authors Xian, Yin, Lyu, Xiaodong, Cheng, Junming, He, Ming, Dai, Zhengnan, Ren, Yixing
Format Journal Article
LanguageChinese
Published China 01.06.2023
Subjects
Immunity, Innate
Lymphocytes
Tretinoin
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Summary:Group 3 innate lymphoid cells (ILC3) are an ILC subset that is characterized by the expression of retinoic acid-related orphan nuclear receptor γt (RORγt) and interleukin 22 (IL-22). This review summarizes the role of ILC3 in coordinating innate immunity and adaptive immunity based on current research and elaborate the significance of ILC3 from the perspective of immune system evolution. In addition, based on immune-related functions, we propose a possible time when ILC3 appears in the evolution of the immune system. And then, the research limitations and prospects are discussed.
ISSN:1007-8738