Value of peripheral blood rare cell EGFR gene amplification detection in the evaluation of benign and malignant pulmonary nodules

• Published in: Zhong hua yi xue za zhi Vol. 104; no. 18; p. 1584
• Main Authors: Li, H, Liu, X Q, Yan, L J, Liu, Y, Zhang, J Q, Xiao, Y N, Li, S Q
• Format: Journal Article
• Language: Chinese
• Published: China 14.05.2024
• Subjects: Adolescent; Adult; Aged; ErbB Receptors - genetics; Female; Gene Amplification; Humans; Lung Neoplasms - diagnosis; Lung Neoplasms - genetics; Lung Neoplasms - pathology; Male; Middle Aged; Multiple Pulmonary Nodules - diagnosis; Multiple Pulmonary Nodules - genetics; Retrospective Studies; ROC Curve; Sensitivity and Specificity; Young Adult
• ISSN: 0376-2491
• DOI: 10.3760/cma.j.cn112137-20231208-01318

To explore the value of detection of epidermal growth factor receptor (EGFR) gene amplification in peripheral blood rare cells in the assessment of benign and malignant pulmonary nodules. A total of 262 patients with pulmonary nodules were selected as the retrospectively study subjects from the Second Affiliated Hospital of Army Military Medical University and Peking Union Medical College Hospital from July 2022 to August 2023. There were 98 males and 164 females, with the age range from 16 to 79 (52.1±12.1) years. The EGFR gene amplification testing was performed on the rare cells enriched from patients' peripheral blood, and the clinical manifestations, CT imaging features, histopathological and/or pathological cytological confirmed results of patients were collected. The receiver operating characteristic (ROC) curve was used to determine the optimal cut-off value of the method of detection of EGFR gene amplification in peripheral blood rare cells, and its diagnostic efficacy was evaluated. Among the 262 pa