New insights on dimethylaminoethanol (DMAE) features as a free radical scavenger

Recently, a number of synthetic drugs used in a variety of therapeutic indications have been reported to have antiaging effects. Among them, Dimethylaminoethanol (DMAE), an anologue of dietylaminoethanol, is a precursor of choline, which in turn allows the brain to optimize the production of acetylc...

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Bibliographic Details
Published inDrug metabolism letters Vol. 6; no. 1; p. 54
Main Authors Malanga, Gabriela, Aguiar, María Belen, Martinez, Hugo D, Puntarulo, Susana
Format Journal Article
LanguageEnglish
Published United Arab Emirates 01.03.2012
Subjects
Animals
Antioxidants - administration & dosage
Antioxidants - pharmacology
Deanol - administration & dosage
Deanol - pharmacology
Dehydroascorbic Acid - analogs & derivatives
Dehydroascorbic Acid - metabolism
Dose-Response Relationship, Drug
Electron Spin Resonance Spectroscopy
Free Radical Scavengers - administration & dosage
Free Radical Scavengers - pharmacology
Free Radicals - metabolism
Hydroxyl Radical - metabolism
Microsomes, Liver - metabolism
Rats
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Summary:Recently, a number of synthetic drugs used in a variety of therapeutic indications have been reported to have antiaging effects. Among them, Dimethylaminoethanol (DMAE), an anologue of dietylaminoethanol, is a precursor of choline, which in turn allows the brain to optimize the production of acetylcholine that is a primary neurotransmitter involved in learning and memory. The data presented here includes new information on the ability of the compound to scavenge specific free radicals, assessed by Electron Spectroscopic Resonance (EPR), to further analyze the role of DMAE as an antioxidant. DMAE ability to directly react with hydroxyl, ascorbyl and lipid radicals was tested employing in vitro assays, and related to the supplemented dose of the compound.
ISSN:1874-0758