Remodeling of the HDL in NIDDM : a fundamental role for cholesteryl ester transfer protein

When the AY gene is expressed in KK mice, the yellow offspring (KKAy mice) become obese, insulin resistant, hyperglycemic, and severely hypertriglyceridemic, yet they maintain extraordinarily high plasma high-density lipoprotein (HDL) levels.

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Bibliographic Details
Published inAmerican journal of physiology: endocrinology and metabolism Vol. 37; no. 6; pp. E1091 - E1098
Main Authors CASTLE, C. K, KUIPER, S. L, BLAKE, W. L, PAIGEN, B, MAROTTI, K. R, MELCHIOR, G. W
Format Journal Article
LanguageEnglish
Published Bethesda, MD American Physiological Society 01.06.1998
Subjects
Biological and medical sciences
Cholesterol
Diabetes
Diabetes. Impaired glucose tolerance
Endocrine pancreas. Apud cells (diseases)
Endocrinopathies
Etiopathogenesis. Screening. Investigations. Target tissue resistance
Medical sciences
Proteins
Rodents
Endocrinopathy
Animal model
Pathophysiology
Enzyme
Hypertriglyceridemia
Apolipoprotein AI
Hydrolases
Esterases
Lipoprotein lipase
Lipoprotein HDL
Non insulin dependent diabetes
Carboxylic ester hydrolases
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Summary:When the AY gene is expressed in KK mice, the yellow offspring (KKAy mice) become obese, insulin resistant, hyperglycemic, and severely hypertriglyceridemic, yet they maintain extraordinarily high plasma high-density lipoprotein (HDL) levels.
ISSN:0193-1849
1522-1555