Analysis of brain volume asymmetry and clinical application in patients with temporal lobe epilepsy with hippocampal sclerosis based on automatic brain segmentation

• Published in: Zhong hua yi xue za zhi Vol. 103; no. 13; p. 991
• Main Authors: Zhang, X N, Cheng, J L, Zhang, Y, Song, C R, Ma, K R, Bai, M, Wang, K F, Mao, X Y
• Format: Journal Article
• Language: Chinese
• Published: China 04.04.2023
• Subjects: Adolescent; Adult; Brain; Epilepsy, Temporal Lobe - diagnosis; Epilepsy, Temporal Lobe - surgery; Female; Hippocampal Sclerosis; Humans; Male; Middle Aged; Retrospective Studies; Temporal Lobe; Young Adult
• ISSN: 0376-2491
• DOI: 10.3760/cma.j.cn112137-20220801-01673

To analyze whole brain structural volume asymmetry in temporal lobe epilepsy with hippocampal sclerosis (TLE-HS) using automated brain segmentation technology, and to investigate the application value of this technology in the diagnosis of TLE-HS and the performance in determining the location the lateralization of epileptogenic focus. Twenty-eight patients with TLE-HS were enrolled in the First Affiliated Hospital of Zhengzhou University from April 2019 to October 2020, including 13 females and 15 males, aged ranged from 18 to 63 (30±12) years, and these patients were divided two group according to the epilepsy lateralization, left TLE-HS(LTLE-HS) group ( =11), right TLE-HS(RTLE-HS) group ( =17) and 28 normal controls [aged ranged from 18 to 49 (29±10) years]. All of these subjects underwent three-dimensional T weighted image (3D T WI). The differences of brain structure and volumes in LTLE-HS, RTLE-HS and normal controls group were retrospectively analyzed, and Pearson's correlation coefficient was used to