Role of wall tension in hypoxic responses of isolated rat pulmonary arteries

The changes in force developed during 40-min exposures to hypoxia (37 +/- 1 mmHg) were recorded in large (0.84 +/- 0.02-mm-diameter) and small (0.39 +/- 0.01-mm-diameter) intrapulmonary arteries during combinations of mechanical wall stretch tensions (passive + active myogenic components), equivalen...

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Bibliographic Details
Published inAmerican journal of physiology. Lung cellular and molecular physiology Vol. 19; no. 6; pp. L1069 - L1077
Main Authors OZAKI, M, MARSHALL, C, AMAKI, Y, MARSHALL, B. E
Format Journal Article
LanguageEnglish
Published Bethesda, MD American Physiological Society 01.12.1998
Subjects
Biological and medical sciences
Blood vessels
Blood vessels and receptors
Fundamental and applied biological sciences. Psychology
Laboratory animals
Lungs
Medical research
Tension
Vertebrates: cardiovascular system
Oxygen
Rat
Arachidonic acid derivatives
Rodentia
Vasoconstriction
Pulmonary artery
Myogenic factor
Prostaglandin F2α
Vasomotricity
Vertebrata
Mammalia
Eicosanoid
Blood vessel
Hypoxia
Surface tension
Circulatory system
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Summary:The changes in force developed during 40-min exposures to hypoxia (37 +/- 1 mmHg) were recorded in large (0.84 +/- 0.02-mm-diameter) and small (0.39 +/- 0.01-mm-diameter) intrapulmonary arteries during combinations of mechanical wall stretch tensions (passive + active myogenic components), equivalent to transmural vascular pressures of 5, 15, 30, 50, and 100 mmHg, and active (vasoconstriction) tensions, stimulated by PGF2alpha in doses of 0, 25, 50, and 75% effective concentrations.
ISSN:1040-0605
1522-1504