Cajal bodies and histone locus bodies: molecular structure and function

The review provides modern classification of evolutionarily conserved coilin-containing nuclear bodies of somatic and germ cells that is based on the characteristic features of their molecular composition and the nature of their functions. The main differences between Cajal bodies and histone locus...

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Bibliographic Details
Published inOntogenez Vol. 45; no. 6; p. 363
Main Authors Khodiuchenko, T A, Krasikova, A V
Format Journal Article
LanguageRussian
Published Russia (Federation) 01.11.2014
Subjects
Amphibians - genetics
Amphibians - metabolism
Animals
Birds - genetics
Birds - metabolism
Female
Genetic Loci - physiology
Histones - genetics
Histones - metabolism
Intranuclear Space - metabolism
Male
Nuclear Proteins - genetics
Nuclear Proteins - metabolism
Oocytes - metabolism
RNA Precursors - genetics
RNA Precursors - metabolism
RNA Processing, Post-Transcriptional - physiology
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Summary:The review provides modern classification of evolutionarily conserved coilin-containing nuclear bodies of somatic and germ cells that is based on the characteristic features of their molecular composition and the nature of their functions. The main differences between Cajal bodies and histone locus bodies, which are involved in the biogenesis of small nuclear spliceosomal and nucleolar RNAs and in the 3'-end processing of histone precursor messenger RNA, respectively, are considered. It is shown that a significant contribution to the investigation of the diversity of coilin-containing bodies was made by the studies on the architecture of the RNA processing machinery in oocyte nuclei in a number of model organisms. The characteristics features of the molecular composition of coilin-containing bodies in the nuclei of growing oocytes (the so-called germinal vesicles) of vertebrates, including amphibians and birds, are described.
ISSN:0475-1450