ATP-dependent GSH and glutathione S-conjugate transport in skate liver : role of an Mrp functional homologue

Multidrug resistance-associated proteins 1 and 2 (Mrp1 and Mrp2) are thought to mediate low-affinity ATP-dependent transport of reduced glutathione (GSH), but there is as yet no direct evidence for this hypothesis. The present study examined whether livers from the little skate (Raja erinacea) expre...

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Published inAmerican journal of physiology: Gastrointestinal and liver physiology Vol. 42; no. 2; pp. G417 - G425
Main Authors REBBEOR, J. F, CONNOLLY, G. C, HENSON, J. H, BOYER, J. L, BALLATORI, N
Format Journal Article
LanguageEnglish
Published Bethesda, MD American Physiological Society 01.08.2000
Subjects
Anatomy & physiology
Bile
Biological and medical sciences
Fish
Fundamental and applied biological sciences. Psychology
Liver
Liver. Bile. Biliary tracts
Vertebrates: digestive system
Digestive system
Liver
Biological transport
Raja erinacea
Bile canaliculi
Marine environment
Vertebrata
Pisces
Animal
Exocrine secretion
Chondrichthyes
ATP
Carrier protein
Bile
Glutathione
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Summary:Multidrug resistance-associated proteins 1 and 2 (Mrp1 and Mrp2) are thought to mediate low-affinity ATP-dependent transport of reduced glutathione (GSH), but there is as yet no direct evidence for this hypothesis. The present study examined whether livers from the little skate (Raja erinacea) express an Mrp2 homologue and whether skate liver membrane vesicles exhibit ATP-dependent GSH transport activity.
ISSN:0193-1857
1522-1547