A descriptive analysis of hyperlipidemia in adult twins in China

• Published in: Zhōnghuá liúxíngbìng zázhì Vol. 44; no. 4; p. 544
• Main Authors: Miao, K, Cao, W H, Lyu, J, Yu, C Q, Wang, S F, Huang, T, Sun, D J Y, Liao, C X, Pang, Y J, Pang, Z C, Yu, M, Wang, H, Wu, X P, Dong, Z, Wu, F, Jiang, G H, Wang, X J, Liu, Y, Deng, J, Lu, L, Gao, W J, Li, L M
• Format: Journal Article
• Language: Chinese
• Published: China 10.04.2023
• Subjects: Adult; China - epidemiology; Diseases in Twins - genetics; Female; Humans; Hyperlipidemias - epidemiology; Hyperlipidemias - genetics; Male; Metabolic Diseases; Middle Aged; Twins, Dizygotic; Twins, Monozygotic - genetics; Young Adult; China
• ISSN: 0254-6450
• DOI: 10.3760/cma.j.cn112338-20221007-00859

To describe the distribution characteristics of hyperlipidemia in adult twins in the Chinese National Twin Registry (CNTR) and explore the effect of genetic and environmental factors on hyperlipidemia. Twins recruited from the CNTR in 11 project areas across China were included in the study. A total of 69 130 (34 565 pairs) of adult twins with complete information on hyperlipidemia were selected for analysis. The random effect model was used to characterize the population and regional distribution of hyperlipidemia among twins. The concordance rates of hyperlipidemia were calculated in monozygotic twins (MZ) and dizygotic twins (DZ), respectively, to estimate the heritability. The age of all participants was (34.2±12.4) years. This study's prevalence of hyperlipidemia was 1.3% (895/69 130). Twin pairs who were men, older, living in urban areas, married,had junior college degree or above, overweight, obese, insufficient physical activity, current smokers, ex-smokers, current drinkers, and ex-drinkers had a hig