Latest Findings on the Function of Immune Metabolism in Tumor Immunity

Metabolic reprogramming, an important hallmark of cancer, helps cancer achieve rapid proliferation. Metabolic changes in tumors regulate multiple metabolic pathways of immune cells, thereby suppressing antitumor immunity. Recent studies have been focused on in-depth investigation into the changes in...

Full description

Saved in:
Bibliographic Details
Published inSichuan da xue xue bao. Journal of Sichuan University. Yi xue ban Vol. 54; no. 3; pp. 497 - 504
Main Authors Yang, Yang, Fan, Dian, Zheng, Bo-Hao, Zhou, Sheng-Tao
Format Journal Article
LanguageChinese
Published China 01.05.2023
Subjects
Immune metabolism
Tumor microenvironment
Immunotherapy
Online AccessGet full text

Cover

More Information
Summary:Metabolic reprogramming, an important hallmark of cancer, helps cancer achieve rapid proliferation. Metabolic changes in tumors regulate multiple metabolic pathways of immune cells, thereby suppressing antitumor immunity. Recent studies have been focused on in-depth investigation into the changes in the metabolism of glucose, amino acids, and lipids. Researchers have also conducted in-depth exploration of the interactive metabolic regulation of tumor cells and immune cells. Targeting various metabolic mechanisms while combining available anti-tumor therapies and enhancing the anti-tumor effects of immunotherapy by satisfying the metabolic demands of immune cells has offered new perspectives for therapies targeting the immune metabolism of tumors and enhancing anti-tumor immune responses. Studies on novel immune checkpoint molecules and cellular immunotherapies are also ongoing. Herein, we reviewed the latest findings on the mechanisms of immune metabolism underlying tumor immunosuppression and their applicati
Bibliography:ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Feature-3
content type line 23
ObjectType-Review-1
ISSN:1672-173X
DOI:10.12182/20230560304