Analysis of the clinical characteristics and efficacy of 20 cases of extranodal Rosai-Dorfman disease in head and neck

To analyze the clinical characteristics and efficacy of extranodal Rosai-Dorfman disease in head and neck. Clinical and pathological features and follow-up of patients who were diagnosed as RDD at Beijing Tongren Hospital of Capital Medical University between May 2008 and November 2016 were analyzed...

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Bibliographic Details
Published inZhong hua yi xue za zhi Vol. 97; no. 29; p. 2284
Main Authors Cui, L, Yue, C L
Format Journal Article
LanguageChinese
Published China 01.08.2017
Subjects
Adult
Aged
Aged, 80 and over
Diagnosis, Differential
Female
Head
Histiocytes
Histiocytosis, Sinus
Humans
Male
Middle Aged
Neck
Retrospective Studies
S100 Proteins
Histiocytosis, sinus
Diagnosis, differential
Treatment
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Summary:To analyze the clinical characteristics and efficacy of extranodal Rosai-Dorfman disease in head and neck. Clinical and pathological features and follow-up of patients who were diagnosed as RDD at Beijing Tongren Hospital of Capital Medical University between May 2008 and November 2016 were analyzed retrospectively. There were a total of 20 extranodal RDD patients in head and neck including 14 females and 6 males, aged from 27 to 86 years (mean 52.5 years). Nose (14 cases) and throat (5 cases) were most commonly involved organs and 5 patients had 2 or more organs involved. Diagnosis depends on biopsy. Histopathologically, the lesions of RDD were characterized by the presence of large histiocytes with emperipolesis. The large sinus histiocytes were positive for S-100 and CD68 protein staining. Diagnostic Errors in 13 patients and operations in all patients were happened. More than 1 operation was performed in 9 recurrence patients. Eight patients were treated by Glucocorticoids and immunosuppressive agents. Al
ISSN:0376-2491
DOI:10.3760/cma.j.issn.0376-2491.2017.29.011