Abnormal platelet Ca2+ handling accompanied by increased cytosolic free Mg2+ in essential hypertension

To test the hypothesis that abnormal platelet Ca2+ handling in essential hypertension results from cellular Mg2+ deficiency, cytosolic free Mg2+ concentration Mg2+ and Ca2+ metabolism were studied in mag-fura 2 and fura 2-loaded platelets from 30 essential hypertensive patients and 30 sexand age-mat...

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Published inAmerican journal of physiology. Regulatory, integrative and comparative physiology Vol. 44; no. 2; pp. R574 - R579
Main Authors HIRAGA, H, OSHIMA, T, YOSHIMURA, M, MATSUURA, H, KAJIYAMA, G
Format Journal Article
LanguageEnglish
Published Bethesda, MD American Physiological Society 01.08.1998
Subjects
Arterial hypertension. Arterial hypotension
Biological and medical sciences
Blood
Blood and lymphatic vessels
Calcium
Cardiology. Vascular system
Experimental diseases
Hypertension
Medical sciences
Human
Hypertension
Serine endopeptidases
Calcium
Enzyme
Pathogenesis
Deficiency
Cardiovascular disease
Thrombin
Peptidases
Platelet
Hydrolases
Intracellular
Magnesium
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Summary:To test the hypothesis that abnormal platelet Ca2+ handling in essential hypertension results from cellular Mg2+ deficiency, cytosolic free Mg2+ concentration Mg2+ and Ca2+ metabolism were studied in mag-fura 2 and fura 2-loaded platelets from 30 essential hypertensive patients and 30 sexand age-matched normotensive controls. Basal cytosolic free Ca2+ concentration (ACa2+Bi) and intracellular Ca2+ discharge capacity were higher in hypertensives than in normotensives (22 +/- 5 vs. 18 +/- 5 nM, P < 0.05; 743 +/- 250 vs. 624 +/- 144 nM, P < 0.05, respectively).
ISSN:0363-6119
1522-1490