E2 and not P4 increases NO release from NANC nerves of the gastrointestinal tract: implications in pregnancy

In women, during pregnancy, there is decreased motility of the gastrointestional tract leading to a delay in gastric emptying and an increase in colonic transit time. Whether the rise in estradiol (E2) or progesterone (P4) is responsible for this effect is controversial.

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Bibliographic Details
Published inAmerican journal of physiology. Regulatory, integrative and comparative physiology Vol. 49; no. 5; pp. R1546 - R1554
Main Authors SHAH, Sangita, NATHAN, Lauren, SINGH, Rajan, YO SHI FU, CHAUDHURI, Gautam
Format Journal Article
LanguageEnglish
Published Bethesda, MD American Physiological Society 01.05.2001
Subjects
Biological and medical sciences
Digestive system
Fundamental and applied biological sciences. Psychology
Nervous system
Pregnancy
Stomach
Vertebrates: digestive system
Human
Stomach
Motility
Nervous control
Digestive system
Enzyme
Gut
Non adrenergic non cholinergic transmission
Gastric emptying
Digestion
Estradiol
Ovarian hormone
Nitric-oxide synthase
Digestive transit
Pregnancy
Nitric oxide
Hormonal regulation
Myenteric plexus
Oxidoreductases
Colon
Progesterone
Sex steroid hormone
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Summary:In women, during pregnancy, there is decreased motility of the gastrointestional tract leading to a delay in gastric emptying and an increase in colonic transit time. Whether the rise in estradiol (E2) or progesterone (P4) is responsible for this effect is controversial.
ISSN:0363-6119
1522-1490