Metabolic syndrome and cardiovascular risk patients under antiretrovirals in a day hospital at Bobo-Dioulasso (Burkina Faso)

• Published in: Bulletin de la Societe de pathologie exotique (1990) Vol. 107; no. 3; p. 151
• Main Authors: Sawadogo, A, Sanou, S, Hema, A, Kamboule, B E, Kabore, N F, Sore, I, Konate, A, Poda, G E A, Zoungrana, J, Sawadogo, A B
• Format: Journal Article
• Language: French
• Published: France 01.08.2014
• Subjects: Adult; Aged; Ambulatory Care Facilities; Antiretroviral Therapy, Highly Active - adverse effects; Burkina Faso - epidemiology; Cardiovascular Diseases - epidemiology; Cardiovascular Diseases - etiology; Cross-Sectional Studies; Female; HIV Infections - drug therapy; HIV Infections - epidemiology; HIV-1; Humans; Male; Metabolic Syndrome - epidemiology; Metabolic Syndrome - etiology; Middle Aged; Risk Factors; Young Adult
• ISSN: 0037-9085
• DOI: 10.1007/s13149-014-0371-8

Highly active antiretroviral therapy (HAART) has reduced morbidity and mortality of HIV but has led to an increasing metabolic cardiovascular risk. A cross-sectional study was conducted from May to September 2011 in Day Care Hospital for HIV-Patients of Bobo-Dioulasso. We included in this study 400 patients infected by HIVon antiretroviral therapy ≥ 6 months selected by a random draw. Metabolic syndrome was assessed according to the definitions of the IDF and ATP-III. The high risk of cardiovascular disease in 10 years was defined by a Framingham score ≥ 20%. The average age of our patients was 41.4 years [20-76]. 17% received an IP. The average duration of PI exposure was 35.5 months and 50.1 months for NNRTI. The prevalence of diabetes was 1.3% (95% CI: 0.5-3) and that of hypertension of 12.0 % (95% CI: 9.3-16). The prevalence of metabolic syndrome according to IDF was 10% (95% CI: 7.3-13.5) and the metabolic syndrome according to ATP-III 12.3% (95% CI: 9.3-16). The body mass index was higher (BMI 25.2 vs. 22.5 kg/m(2), p <10(-3) with ATPIII and BMI 26.6 vs. 22.4 kg/m(2), p <10(-3) with IDF), and duration exposure to ARVs longer in patients with metabolic syndrome regardless of the definition used (58.6 months vs 27.9 months). High cardiovascular risk was present in 1.8% (95% CI: 0.8 to 3.7) of our patients, all male more than half (n=4/7) of them were smoking. The choice of antiretroviral therapy must take into account its potential long-term toxicity. It should also strengthen supervision.