Overexpression of protein kinase C-δ increases tight junction permeability in LLC-PK1 epithelia

The Ca2+ -independent delta-isoform of protein kinase C (PKC-delta) was overexpressed in LLC-PK1 epithelia and placed under control of a tetracycline-responsive expression system.

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Bibliographic Details
Published inAmerican Journal of Physiology: Cell Physiology Vol. 44; no. 2; pp. C544 - C554
Main Authors MULLIN, J. M, KAMPHERSTEIN, J. A, LAUGHLIN, K. V, CLARKIN, C. E. K, MILLER, R. D, SZALLASI, Z, KACHAR, B, SOLER, A. P, ROSSON, D
Format Journal Article
LanguageEnglish
Published Bethesda, MD American Physiological Society 01.08.1998
Subjects
Biological and medical sciences
Cell interactions, adhesion
Cellular biology
Enzymes
Fundamental and applied biological sciences. Psychology
Molecular and cellular biology
Permeability
Pharmacology
Proteins
Protein kinase C
Cell permeability
Enzyme
Isozyme
Transferases
In vitro
Kidney
Pig
Vertebrata
Cell line
Mammalia
Paracellular transport
Tight junction
Artiodactyla
Ungulata
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Summary:The Ca2+ -independent delta-isoform of protein kinase C (PKC-delta) was overexpressed in LLC-PK1 epithelia and placed under control of a tetracycline-responsive expression system.
ISSN:0363-6143
1522-1563