Effect and mechanism of Jingqi Yukui Capsules on gastric ulcer mucosa healing quality: based on network pharmacology and animal experiment

This study aims to identify the active components and the mechanism of Jingqi Yukui Capsules(JQYK) in the treatment of gastric ulcer based on network pharmacology, and verify some key targets and signaling pathways through animal experiment. To be specific, first, the active components and targets o...

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Published inZhongguo zhongyao zazhi Vol. 47; no. 5; p. 1350
Main Authors Fan, Min-Jue, Duan, Yong-Qiang, Li, Neng-Lian, Yang, Xiao-Yi, Ma, Jun, Gong, Zi-Han, Wang, Dao-Kun
Format Journal Article
LanguageChinese
Published China 01.03.2022
Subjects
Animal Experimentation
Animals
Capsules
Gastric Mucosa - metabolism
Humans
Network Pharmacology
Rats
Stomach Ulcer - drug therapy
Stomach Ulcer - genetics
Jingqi Yukui Capsules
quality of ulcer healing
gastric ulcer
inflammation
network pharmacology
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Summary:This study aims to identify the active components and the mechanism of Jingqi Yukui Capsules(JQYK) in the treatment of gastric ulcer based on network pharmacology, and verify some key targets and signaling pathways through animal experiment. To be specific, first, the active components and targets of JQYK were retrieved from a Bioinformatics Analysis Tool for Molecular Mechanism of Traditional Chinese Medicine(BATMAN-TCM) and Traditional Chinese Medicine Systems Pharmacology Database and Analysis Platform(TCMSP), and the targets of gastric ulcer from GeneCards and Online Mendelian Inheritance in Man(OMIM) with the search term "gastric ulcer". The common targets of the two were the potential targets of the prescription for the treatment of the di-sease. Then, protein-protein interaction(PPI) network of key targets were constructed based on STRING and Cytoscape 3.7.2, followed by Kyoto Encyclopedia of Genes and Genomes(KEGG) pathway enrichment by matescape database and pathway visualization by Omicshare. For th
ISSN:1001-5302
DOI:10.19540/j.cnki.cjcmm.20211117.702