Biological strategies supporting the orthopaedic treatment

Damage to the musculoskeletal system significantly impairs mobility and quality of life, limiting everyday activities. For a successful orthopedic treatment, anatomical, physiological and biomechanical factors must be taken into account as they all influence tissue healing. It is therefore of crucia...

Full description

Saved in:
Bibliographic Details
Published inPostępy biochemii Vol. 69; no. 4; p. 310
Main Authors Pawlak, Maciej, Wałecka, Joanna, Bąkowski, Paweł, Tyczewska, Agata, Grzywacz, Kamilla
Format Journal Article
LanguagePolish
Published Poland 30.01.2024
Subjects
Humans
Intercellular Signaling Peptides and Proteins - metabolism
Intercellular Signaling Peptides and Proteins - therapeutic use
Mesenchymal Stem Cells
Orthopedic Procedures - methods
Online AccessGet more information

Cover

More Information
Summary:Damage to the musculoskeletal system significantly impairs mobility and quality of life, limiting everyday activities. For a successful orthopedic treatment, anatomical, physiological and biomechanical factors must be taken into account as they all influence tissue healing. It is therefore of crucial importance to support traditional treatment with biological therapies, as they facilitate the regeneration of the tissue microarchitecture. Such orthobiologics work at the cellular level (orthobiologics rich in mesenchymal cells or growth factors) or at the tissue level (matrices for repairing e.g. cartilage). In this review, we describe the most frequently used orthobiologics rich in mesenchymal cells (bone marrow, autologous adipose tissue, tenocytes, umbilical cord, urine and bursa) and growth factors, presenting the molecular basis of their functioning and their clinical effectiveness.
ISSN:0032-5422
DOI:10.18388/pb.2021_505