Sarcoidosis--granulomatosis: the modern view of the etiology and pathogenesis with clinical cases review

• Published in: Likars'ka sprava no. 1-2; pp. 3 - 15
• Main Authors: Kazmirchuk, V E, Tsarik, V V, Mal'tsev, D V, Ishchenko, M I
• Format: Journal Article
• Language: Russian
• Published: Ukraine 01.01.2014
• Subjects: Adult; Child, Preschool; Cytokines - immunology; Diagnosis, Differential; Epstein-Barr Virus Infections - drug therapy; Epstein-Barr Virus Infections - etiology; Epstein-Barr Virus Infections - immunology; Epstein-Barr Virus Infections - virology; Granuloma - drug therapy; Granuloma - etiology; Granuloma - immunology; Granuloma - virology; Herpesvirus 4, Human - isolation & purification; Herpesvirus 6, Human - isolation & purification; Humans; Male; Middle Aged; Roseolovirus Infections - drug therapy; Roseolovirus Infections - etiology; Roseolovirus Infections - immunology; Roseolovirus Infections - virology; Sarcoidosis - drug therapy; Sarcoidosis - etiology; Sarcoidosis - immunology; Sarcoidosis - virology; Treatment Outcome
• ISSN: 1019-5297

Diagnostic criteria of sarcoidosis were offered in the 60-ies of XX century, however today the problem of sarcoidosis is difficult for understanding the different specialists and early detection. The development of laboratory diagnostic of viral infections and introduction of polymerase chain reaction (PCR) has greatly improved the level of diagnosis of herpes infections, reveal the previously unknown etiology of many diseases: sarcoidosis (granulomatosis), migraine, multiple sclerosis, cystic prenatal brain damage, convulsions, Hodgkin's disease and others. Sarcoidosis is the set of clinical symptoms (fatigue, shortness of breath, coughing, heaviness in the chest), laboratory, radiological and histopathological data that allow the doctor to diagnose, predict prognosis and treatment policy. Most often, sarcoidosis affects the lungs and thoracic lymph nodes. In the last period for 2011-2013 in 2930 immunologically tested patients the sarcoidosis was confirmed in 146. Primarily these patients were exposed to different diagnosis--COPD, pneumonia, tuberculosis, lung cancer. Among patients with sarcoidosis on the first place in frequency of detection were EBV and HHV-6. We were the first in 2000, described the Epstein-Barr virus as the causative factor of sarcoidosis, and has been hypothesized the immunopathology of sarcoidosis and principles of individual immunotherapy with a resolution of the granulomatous process in 92 % of cases. Subsequently, this association has been and illustrates the relationship to other viruses (HHV-6, HHV-8) demonstrated by other authors.