Clinical characteristics and correlative factors of dry eye disease associated with graft-versus-host disease

• Published in: Chung-hua yen k'o tsa chih Vol. 59; no. 4; p. 295
• Main Authors: Zhuang, X Y, Sun, Z T, Wang, Y M, Que, L J, Zhang, X F
• Format: Journal Article
• Language: Chinese
• Published: China 11.04.2023
• Subjects: Adult; Cornea - pathology; Dry Eye Syndromes - etiology; Female; Graft vs Host Disease - complications; Graft vs Host Disease - metabolism; Hematopoietic Stem Cell Transplantation - adverse effects; Humans; Male; Middle Aged; Retrospective Studies; Young Adult
• ISSN: 0412-4081
• DOI: 10.3760/cma.j.cn112142-20220801-00370

To investigate the clinical features of dry eye disease in patients with graft-versus-host disease (GVHD) and to identify the correlative factors that contribute to its severity. It was a retrospective case series study. A total of 62 patients with dry eye disease caused by GVHD after allogeneic hematopoietic stem cell transplantation (HSCT) were recruited from the First Affiliated Hospital of Soochow University between 2012 and 2020. The study population comprised 38 males (61%) and 24 females (39%), with an average age of (35.29±11.75) years. Only the right eye of each patient was evaluated. The patients were divided into two groups based on the severity of corneal epitheliopathy: a mild group (15 eyes) and a severe group (47 eyes). Demographic information, including gender, age, primary disease, type of allogeneic HSCT, donor-to-recipient information, source of hematopoietic stem cells, systemic GVHD, and the time from HSCT to the first visit, was collected. Ophthalmologic assessments, including the Schirm