Proteomics and PCOS: Is it here the missing link? Literature review

Polycystic ovary syndrome (PCOS) is known as a common gynecologic and endocrinology disease with multiple short and long-term consequences. It is one of the most common causes for hyperandrogenism and anovulation, increases the risk for metabolic syndrome, type 2 diabetes and cardiovascular disease....

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Published inGinecologia y obstetricia de Mexico Vol. 83; no. 10; pp. 614 - 626
Main Authors Carmona-Ruiz, Israel Obed, Saucedo de la Llata, Eric, Moraga-Sánchez, Maria Rosa, Hernáez-Sánchez, Maria Luisa, Gutiérrez-Blázquez, Maria Dolores, Romeu-Sarrió, Alberto
Format Journal Article
LanguageSpanish
Published Mexico 01.10.2015
Subjects
Biomarkers - metabolism
Female
Genetic Predisposition to Disease
Humans
Polycystic Ovary Syndrome - complications
Polycystic Ovary Syndrome - etiology
Polycystic Ovary Syndrome - physiopathology
Proteomics - methods
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Summary:Polycystic ovary syndrome (PCOS) is known as a common gynecologic and endocrinology disease with multiple short and long-term consequences. It is one of the most common causes for hyperandrogenism and anovulation, increases the risk for metabolic syndrome, type 2 diabetes and cardiovascular disease. Its etiology remains unclear. PCOS is thought to be the result of the interaction between predisposing genetic variants with environmental factors and strongly depends on ethnicity. Proteomics allows the study of several hundreds or thousands of proteins in order to reveal physiological state of a tissue or an organ at the molecular level and to identify disease-specific biomarkers. Its use on PCOS patients will permit us to identify molecules that are involved in the PCOS pathology so we can develop specific diagnostic and management approaches.
Bibliography:ObjectType-Article-2
SourceType-Scholarly Journals-1
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ObjectType-Review-3
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ISSN:0300-9041