A twelve-years-old girl with multiloculated gynandroblastoma CD99 negative: case report

• Published in: Archivos argentinos de pediatría Vol. 112; no. 4; pp. e142 - e146
• Main Authors: Sierra-Avendaño, Jairo Alonso, García-Pino, Ricardo, Pérez-García, Gabriel Eduardo
• Format: Journal Article
• Language: Spanish
• Published: Argentina 01.08.2014
• Subjects: 12E7 Antigen; Antigens, CD - blood; Biomarkers, Tumor - blood; Cell Adhesion Molecules - blood; Child; Female; Humans; Ovarian Neoplasms - blood; Ovarian Neoplasms - pathology; Sex Cord-Gonadal Stromal Tumors - blood; Sex Cord-Gonadal Stromal Tumors - pathology
• ISSN: 1668-3501
• DOI: 10.1590/S0325-00752014000400013

The ginandroblastoma is an extremely rare ovarian tumor which shows components of granulosa cells and Sertoli/Leydig cells. We describe a case of a twelve-years-old girl who presented abnormal uterine bleeding and progressively growing intraabdominal mass associated with menorrhagia, CA-125 60.4 UI/mL and extension studies reporting cystic mass in the left ovary. She underwent oophorectomy. Pathological study shows a multilocular tumor filled with serous material. Many Call-Exner bodies were observed in the histopathological analysis, 45% of Sertoli/Leydig cells. Immunohistochemistry was reactive for inhibin, calretinin and pCK while AE1/AE3 and CD99 markers were negative. This is the first case report about a multiloculated gynandroblastoma, negative for CD99 in a 12-years-old girl. Thus, the study of this clinical case represents a systematic approach for tumors of the sex cord cells.