Clinical case of the month. A rare case of arthritis and fever

We present the case report ofa 28 year old male presenting with recurrent fever episodes and arthralgia. Based on the presence of an inflammatory syndrome, a hyperferritinemia, a salmon-pink rash and recurrent fever episodes, the diagnosis of an adult onset Still's disease (AOSD) was made. A tr...

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Bibliographic Details
Published inRevue médicale de Liège Vol. 68; no. 7-8; p. 423
Main Authors Rinkin, C, Van Durme, C, Fautrel, B, Malaise, M
Format Journal Article
LanguageFrench
Published Belgium 01.07.2013
Subjects
Adult
Anti-Inflammatory Agents, Non-Steroidal - therapeutic use
Antibodies, Monoclonal - therapeutic use
Arthralgia - etiology
Fever - etiology
Glucocorticoids - therapeutic use
Humans
Infliximab
Male
Still's Disease, Adult-Onset - diagnosis
Still's Disease, Adult-Onset - drug therapy
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Summary:We present the case report ofa 28 year old male presenting with recurrent fever episodes and arthralgia. Based on the presence of an inflammatory syndrome, a hyperferritinemia, a salmon-pink rash and recurrent fever episodes, the diagnosis of an adult onset Still's disease (AOSD) was made. A treatment with corticosteroids was started. During the following years, the corticosteroids could not be tapered. Eventually, a treatment with anakinra, an interleukin 1 (IL-1) receptor antagonist was started, allowing tapering of the corticosteroids. This case report supports the possible role of IL-1 in the pathogenesis ofAOSD, possibly through the inflammasome.
ISSN:0370-629X