MRI findings of renal cell carcinoma associated with Xp11.2 translocations/TFE3 gene fusions

• Published in: Zhong hua yi xue za zhi Vol. 96; no. 33; p. 2635
• Main Authors: Zhong, Y, Wang, H Y, Chen, X, Guo, A T, Ma, L, Wang, Y W, Ye, H Y
• Format: Journal Article
• Language: Chinese
• Published: China 06.09.2016
• Subjects: Adolescent; Adult; Basic Helix-Loop-Helix Leucine Zipper Transcription Factors; Carcinoma, Renal Cell; Chromosomes, Human, X; Female; Gene Fusion; Humans; Kidney; Kidney Neoplasms; Lipids; Lymphadenopathy; Magnetic Resonance Imaging; Male; Middle Aged; Necrosis; Retrospective Studies; Translocation, Genetic; Young Adult
• ISSN: 0376-2491
• DOI: 10.3760/cma.j.issn.0376-2491.2016.33.007

To analyze MRI findings of renal cell carcinoma associated with Xp11.2 translocation-TFE gene fusion(Xp11.2 RCC). MR imaging features of eleven patients with pathologically-proved Xp11.2 RCC were retrospectively analyzed from December 2008 to December 2015. The following MRI features of the lesions were analyzed in the study: location, maximal diameter, signal intensity, hemorrhage, necrosis, cystic change, enhancement features and metastasis. The data was analyzed by using test. Four men and seven women (mean age, 35.2 years; age range, 15-49 years) were included. Tumors occurred in the right kidney in 5 cases and the left kidney in 6 cases. On T WI tumors showed heterogeneously hypo-intensity and iso-intensity, hyper-intensity in 10 cases, 1 cases, respectively. On T WI tumors showed heterogeneously slight hypo-intensity, heterogeneously slight hyper-intensity and hyper-intensity in 6 cases, 4 cases, 1 case, respectively. On DWI tumors showed hyper-intensity and heterogeneously slight hype-intensity in 2 ca