Diagnostic value of different serological markers and correlation analysis with disease phenotype in inflammatory bowel disease

• Published in: Zhong hua yi xue za zhi Vol. 102; no. 47; p. 3743
• Main Authors: Tang, H, Tan, B, Shen, B B, Zhang, S L, Qian, J M
• Format: Journal Article
• Language: Chinese
• Published: China 20.12.2022
• Subjects: Antibodies, Antineutrophil Cytoplasmic; Autoantibodies; Biomarkers; Colitis, Ulcerative - diagnosis; Constriction, Pathologic; Crohn Disease - diagnosis; Female; Humans; Inflammatory Bowel Diseases - diagnosis; Male; Phenotype; Retrospective Studies
• ISSN: 0376-2491
• DOI: 10.3760/cma.j.cn112137-20220418-00834

To explore the diagnostic value of different serological markers and the correlation with disease phenotype in inflammatory bowel disease (IBD). The clinical data of 445 IBD patients in Peking Union Medical College Hospital from June 2010 to December 2020 were retrospectively collected, including 223 cases of ulcerative colitis (UC) [111 males, 112 females, with a median age of 46(20,79) years] and 222 cases of Crohn's disease (CD) [147 males, 75 females, with a median age of 39 (19, 72) years]. The positive rates of serum anti-neutrophil cytoplasmic antibodies (ANCA), anti-Saccharomyces cerevisiae antibodies (ASCA), goblet cell autoantibodies (GAB) and pancreatic autoantibodies (PAB) in the two groups were analyzed. The sensitivity, specificity, positive predictive value and negative predictive value of UC and CD were calculated. Logistic regression was performed to analyze the relationship between different combinations of antibodies and disease phenotype. The positive rates of ASCA and PAB in CD patients w