Influence of the Ratio of Peripheral Hemoglobin-to-Red Cell Distribution width on the Prognosis of Patients with Diffuse Large B-cell Lymphoma

• Published in: Zhongguo shi yan xue ye xue za zhi Vol. 30; no. 3; p. 765
• Main Authors: Dong, Xue-Yan, Tang, Guo-Feng, Chen, Wei, Cao, Jiang, Cheng, Hai, Li, Zhen-Yu, Xu, Kai-Lin
• Format: Journal Article
• Language: Chinese
• Published: China 01.06.2022
• Subjects: Erythrocyte Indices; Hemoglobins; Humans; Lymphoma, Large B-Cell, Diffuse - pathology; Prognosis; Retrospective Studies; hemoglobin; red cell distribution width; diffuse large B-cell lymphoma
• ISSN: 1009-2137
• DOI: 10.19746/j.cnki.issn.1009-2137.2022.03.017

To investigate the influence of peripheral hemoglobin (Hb)-to-red cell distribution width (RDW) ratio (HRR) on the prognosis of patients with diffuse large B-cell lymphoma (DLBCL). Data of 265 patients with diffuse large B-cell lymphoma (DLBCL) at the Affiliated Hospital of Xuzhou Medical University from January 2014 to December 2019 were retrospectively analyzed. 132 healthy people in the same period were used as normal control group. The best cut-off points of HRR was determined by receiver operating characteristics (ROC) curve; the chi-square test was used to analyze the correlation of clinical characteristics with HRR; the Kaplan-Meier method was used to compare the overall survival (OS) and progression-free survival (PFS) of HRR patients in different groups; the Cox proportional risk model was used for univariate and multivariate analysis. The best cut-off value of HRR was 0.936, which was divided into low HRR group and high HRR group. The low HRR group had a higher ECOG score, higher incidence of advanc