Association between functional dyspepsia and serum levels of brain-gut peptides in children

• Published in: Zhongguo dang dai er ke za zhi Vol. 24; no. 4; p. 387
• Main Authors: Wang, Dong-Wei, Ye, Xiao-Lin, Wu, Jie
• Format: Journal Article
• Language: Chinese
• Published: China 15.04.2022
• Subjects: Abdominal Pain; Brain; Calcitonin Gene-Related Peptide; Child; Dyspepsia - diagnosis; Ghrelin; Humans; Calcitonin gene-related peptide; Nesfatin-1; Ghrelin; Child; Functional dyspepsia
• ISSN: 1008-8830
• DOI: 10.7499/j.issn.1008-8830.2112029

To study the association between functional dyspepsia (FD) and serum levels of brain-gut peptides including calcitonin gene-related peptide (CGRP), nesfatin-1, and ghrelin in children. A total of 38 children with FD who attended Shengjing Hospital of China Medical University from November 2019 to December 2020 were enrolled as the FD group. Thirty-four healthy children were enrolled as the control group. Serum samples were collected from all of the children. Enzyme-linked immunosorbent assay was used to measure serum levels of CGRP, ghrelin, and nesfatin-1 for comparison between the two groups. The scores of clinical symptoms were determined for the children with FD. Spearman rank correlation analysis was used to investigate the correlation of symptom scores with the serum levels of brain-gut peptides. The FD group had significantly higher serum levels of nesfatin-1 and CGRP than the control group ( <0.05), while there was no significant difference in the serum level of ghrelin between the two groups ( >0.05)