Pathogenesis of ferroptosis on chronic kidney disease and traditional Chinese medicine intervention: a review

• Published in: Zhongguo zhongyao zazhi Vol. 49; no. 10; p. 2629
• Main Authors: Yang, Bi-Ying, Liu, Xiang, Hu, Shuang, Peng, Ya-Jun, Zhang, Wei-Ning, Liu, Bing-Long, He, Ze-Yun
• Format: Journal Article
• Language: Chinese
• Published: China 01.05.2024
• Subjects: Animals; Drugs, Chinese Herbal - therapeutic use; Ferroptosis - drug effects; Humans; Iron - metabolism; Medicine, Chinese Traditional; Renal Insufficiency, Chronic - drug therapy; Renal Insufficiency, Chronic - metabolism; iron metabolism; chronic kidney disease; Chinese herbal formulas; ferroptosis; antioxidant system; lipid peroxidation; active ingredients in traditional Chinese medicine
• ISSN: 1001-5302
• DOI: 10.19540/j.cnki.cjcmm.20240111.701

Chronic kidney disease(CKD) is an insidious disease that has become a significant global public health issue due to its high incidence rate, low awareness, low diagnostic rate, poor prognosis, and high medical costs. Recent studies have shown that CKD development is associated with varying degrees of ferroptosis features. Traditional Chinese medicine(TCM) can regulate iron metabolism, lipid peroxidation, antioxidant systems to inhibit ferroptosis and delay the progression of CKD. Consequently, the intervention mechanism of ferroptosis has become one of the focuses of CKD research. TCM has thousands of years of traditional experience and wisdom. It focuses on the overall regulation of human body functions and can stimulate the body's disease resistance and recovery capabilities, which has certain advantages in treating CKD. However, there is currently a lack of comprehensive articles on the application of TCM in intervening ferroptosis to treat CKD and the pathogenesis of ferroptosis in CKD. Therefore, this ar