Features of anesthesia in rats at abdominal operations

• Published in: Ėksperimental'nai͡a︡ i klinicheskai͡a︡ gastroėnterologii͡a no. 5; p. 62
• Main Authors: Smirnova, A V, Lagutina, L D, Trubitsina, I E, Vasnev, O S, Ianova, O B
• Format: Journal Article
• Language: Russian
• Published: Russia (Federation) 2012
• Subjects: Anesthesia, General - adverse effects; Anesthesia, General - methods; Anesthetics - adverse effects; Anesthetics - pharmacology; Animals; Budd-Chiari Syndrome - chemically induced; Digestive System Surgical Procedures - adverse effects; Digestive System Surgical Procedures - methods; Drug Combinations; Female; Postoperative Complications - chemically induced; Rats; Tiletamine - adverse effects; Tiletamine - pharmacology; Zolazepam - adverse effects; Zolazepam - pharmacology
• ISSN: 1682-8658

Nowadays, in Russia, diethyl ether is the most popular narcosis for rodent and particular rats. We had tested the new methods based on Zoletil 100 + XylaVet (15 mg/kg and 15-10-5 mg/kg) respectively. 6 conventional female rats were treated with this narcosis. The rats, early have narcotized by diethyl ether were investigated as control group. All of 6 treated with new narcosis animals died in early post-operative time. Interestingly enough, that organ toxicity, except neurologic toxicity, was not described in literature and manuals. We assume that this new narcosis is the cause of portal thromboses.