Association between the structure of intestinal flora and inflammatory response in children with sepsis: a prospective cohort study

• Published in: Zhongguo dang dai er ke za zhi Vol. 26; no. 6; p. 567
• Main Authors: Lyv, Zhao-Yi, Wang, Liu-Ju, Xu, Mei-Xian, Bai, Xin-Feng, Cao, Li-Jing
• Format: Journal Article
• Language: Chinese
• Published: China 15.06.2024
• Subjects: C-Reactive Protein - analysis; Child; Child, Preschool; Cohort Studies; Cytokines - analysis; Cytokines - blood; Female; Gastrointestinal Microbiome; Humans; Infant; Inflammation; Leukocyte Count; Male; Prospective Studies; Sepsis - blood; Sepsis - microbiology; Inflammatory response; Sepsis; Correlation; Intestinal flora; Child
• ISSN: 1008-8830
• DOI: 10.7499/j.issn.1008-8830.2312113

To investigate the structural characteristics of intestinal flora in children with sepsis and its association with inflammatory response. A prospective cohort study was conducted. The children with sepsis who were admitted from December 2021 to January 2023 were enrolled as the sepsis group, and the children with non-sepsis who were admitted during the same period were enrolled as the non-sepsis group. The two groups were compared in terms of the distribution characteristics of intestinal flora, peripheral white blood cell count (WBC), C reactive protein (CRP), and cytokines, and the correlation of the relative abundance of fecal flora with WBC, CRP, and cytokines was analyzed. At the genus level, compared with the non-sepsis group, the sepsis group had significantly lower relative abundance of , , and and significantly higher relative abundance of , , and ( <0.05). At the phylum level, was the dominant phylum (37.46%) in the group of children with a score of ≤70 from the Pediatric Critical Illness Score (PIC