Comparative Study of Rapid Antigen Test Reagents for Group A Streptococcus spp.

We compared rapid antigen detection kits widely used for the rapid diagnosis of group A streptococcal pharyngitis, evaluating their minimum detection sensitivity and operability in five levels. Five kits based on the immunochromatographic method were used: ImunoAce Strep A (Tauns), ImunoAce Strep A...

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Published inRinsho Biseibutsu Jinsoku Shindan Kenkyukai shi = JARMAM : Journal of the Association for Rapid Method and Automation in Microbiology Vol. 32; no. 1; p. 1
Main Authors Nakano, Eisuke, Koyama, Shinobu, Imai, Megumi, Machida, Yoshimi, Sakanoue, Takefumi, Nakahara, Tsuyoshi, Yaguchi, Yuji, Tamai, Kiyoko, Ohkusu, Kiyofumi
Format Journal Article
LanguageJapanese
Published Japan 26.12.2022
Subjects
Humans
Pharyngitis - diagnosis
Pharyngitis - microbiology
Reagent Kits, Diagnostic
Streptococcal Infections - diagnosis
Streptococcus pyogenes
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Summary:We compared rapid antigen detection kits widely used for the rapid diagnosis of group A streptococcal pharyngitis, evaluating their minimum detection sensitivity and operability in five levels. Five kits based on the immunochromatographic method were used: ImunoAce Strep A (Tauns), ImunoAce Strep A Neo (Tauns), Quick Navi-StrepA2 (Denka), Quick Vue Dipstick Strep A (SB Bioscience) and RapidTesta Strep A (SEKISUI MEDICAL). Thirteen strains were tested: 10 clinical isolates of , 2 strains of subsp. (SDSE), and ATCC 19615. All kits had the same or higher minimum detection sensitivity than previously reported. ImunoAce StrepA Neo had the highest detection sensitivity and the best overall evaluation among the group A streptococcal rapid antigen detection kits used in this study. The detection sensitivity of SDSE with group A polysaccharide antigen was comparable to that of . Although culture tests are necessary to confirm the causative organism, SDSE may present with clinical symptoms similar to those of , and detection with a rapid antigen detection kit may be of therapeutic value.
ISSN:0915-1753