Analysis on the relationship of molecular transmission between HIV infected men who have sex with men and their sexual partners

• Published in: Zhōnghuá liúxíngbìng zázhì Vol. 42; no. 12; p. 2106
• Main Authors: Ding, X B, Luo, M Y, Pan, X H, Zhang, J F, Fan, Q, Jiang, J, Xia, Y, Guo, Z H
• Format: Journal Article
• Language: Chinese
• Published: China 10.12.2021
• Subjects: Cross-Sectional Studies; HIV Infections - epidemiology; Homosexuality, Male; Humans; Male; Phylogeny; Sexual and Gender Minorities; Sexual Behavior; Sexual Partners
• ISSN: 0254-6450
• DOI: 10.3760/cma.j.cn112338-20210811-00634

To investigate the relationship between HIV-infected men who have sex with men and their sexual partners in Zhejiang province. A cross-sectional survey was conducted to recruit newly confirmed HIV/AIDS among MSM from 2015 to 2017, including sexual partner identification and molecular epidemiological study. Plasma was collected to extract RNA, and the gene of HIV-1 was amplified by RT-PCR/nested PCR. Phylogenetic tree and molecular transmission cluster were analyzed to identify the transmission relationship between sexual partners. A total of 937 HIV/AIDS among MSM were recruited to promote HIV testing for their sexual partners, and 173 positive sexual partners were identified. 50.8% (61/120) of the gene sequences were clustered among the positive sex partners. Seven pairs of clustered sex partners combined with the results of recent infection preliminarily determined the transmission direction. In the clusters, there were statistical differences between the partners who were diagnosed in the same year ( =12.1