Role of helminth antigens in the abnormal mitosis of bone marrow cells in laboratory animals

The intraabdominal administration of somatic extracts of the cestodes Hydatigera taeniaformis Batsch 1786, Lamarck, 1816 and Diphyllobothrium latum Linnaeus, 1758 and the nematodes Anisakis simplex larva Rudolphi 1809, Toxocara canis Railliet et Henry, 1912 in albino mice proved that these helminths...

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Published inMeditsinskaia parazitologiia i parazitarnye bolezni no. 3; p. 33
Main Authors Sivkova, T N, Tatarnikova, N A, Berezhko, V K, Benediktov, I I
Format Journal Article
LanguageRussian
Published Russia (Federation) 01.07.2013
Subjects
Animals
Anisakis - chemistry
Antigens, Helminth - isolation & purification
Antigens, Helminth - pharmacology
Bone Marrow Cells - drug effects
Bone Marrow Cells - pathology
Diphyllobothrium - chemistry
Immunodiffusion
Injections, Intraperitoneal
Male
Mice
Mitosis - drug effects
Mitotic Index
Rabbits
Time Factors
Toxocara canis - chemistry
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Summary:The intraabdominal administration of somatic extracts of the cestodes Hydatigera taeniaformis Batsch 1786, Lamarck, 1816 and Diphyllobothrium latum Linnaeus, 1758 and the nematodes Anisakis simplex larva Rudolphi 1809, Toxocara canis Railliet et Henry, 1912 in albino mice proved that these helminths had a karyopathic effect on the bone marrow cells of the animals. The antigenic composition of these extracts was investigated using the agar gel immunodiffusion test. The antigenic composition of the parasites was ascertained to affect their karyopathic properties. The amount of antigens and their foreignness caused a marked karyopathic effect on the bone marrow cells of laboratory animals during intraabdominal administration.
ISSN:0025-8326