Effect of Bushen Qiangdu Recipe on Histomorphology and Wnt Pathway of DBA/1 Mice

• Published in: Zhongguo Zhong xi yi jie he za zhi Vol. 37; no. 1; p. 94
• Main Authors: Yang, Wen-Xue, Yan, Xiao-Ping, Jin, Yue, Zhou, Tong-Liang, Zhang, Lan, Tao, Qing-Wen, Kong, Wei-Ping
• Format: Journal Article
• Language: Chinese
• Published: China 01.01.2017
• ISSN: 1003-5370

Objective To observe the effect of Bushen Qiangdu Recipe (BQR) on the entheses ossification histomorphology of articular ligament of DBA/1 mice with spontaneous ankylosing spondylitis (AS) , and to study its mechanism for prevention and treatment of AS. Methods Thirty 12-week old male DBA/1 mice were randomly divided into the model group, the positive drug group, low, medium, high dose BQR groups, 6 in each group. Another 6 C57BLE mice of the same age were recruited as a blank control group. BQR containing 11. 25, 22. 50, 45.00 g/kg crude drugs was respectively adminis- tered to mice in low, medium, high dose BQR groups by gastrogavage, 0. 2 mL for each mouse, once per day. Celecoxib Capsule (0. 2 mL/0. 8 mg for each mouse, once per day) was administered to mice in the positive drug group by gastrogavage. Equal volume of normal saline was administered to mice in the model group and the blank control group by gastrogavage. All mice were fed and intragastically adminis- tered for 12 successive weeks. Body weigh