Erythrocytic enzymopathy in Uzbekistan

Erythrocyte enzymes participate in the main interactions promoting utilization of glucose-glycolytic, pentosophosphate cycles and glutation system. In this report we study on erythrocyte G6PD deficiency which is the impairment related to the gender and expressed with development of acute drug-associ...

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Bibliographic Details
Published inLikars'ka sprava no. 7-8; p. 73
Main Authors Bakhramov, S M, Ashrabhodzhaeva, K K
Format Journal Article
LanguageRussian
Published Ukraine 01.10.2011
Subjects
Alleles
Anemia, Hemolytic - enzymology
Anemia, Hemolytic - ethnology
Anemia, Hemolytic - genetics
Anemia, Hemolytic, Congenital Nonspherocytic - enzymology
Anemia, Hemolytic, Congenital Nonspherocytic - ethnology
Anemia, Hemolytic, Congenital Nonspherocytic - genetics
Carrier State
Erythrocytes - drug effects
Erythrocytes - enzymology
Ethnic Groups
Female
Gene Frequency
Genotype
Glucosephosphate Dehydrogenase - genetics
Glucosephosphate Dehydrogenase Deficiency - enzymology
Glucosephosphate Dehydrogenase Deficiency - ethnology
Glucosephosphate Dehydrogenase Deficiency - genetics
Hemolysis - drug effects
Humans
Male
Oxidants - adverse effects
Phenotype
Prescription Drugs - adverse effects
Prevalence
Uzbekistan - epidemiology
Uzbekistan
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Summary:Erythrocyte enzymes participate in the main interactions promoting utilization of glucose-glycolytic, pentosophosphate cycles and glutation system. In this report we study on erythrocyte G6PD deficiency which is the impairment related to the gender and expressed with development of acute drug-associated hemolytic anemia. Out of 13187 studied subjects 122 showed carrying of deficiency of erythrocyte G6PD activity, from them 98 (80.3%) subjects were male, and 24 (19.7%) female. As a whole, among the revealed in the population studies, and also verified in clinic of the persons with deficiency of erythrocyte G6PD there were marked different pathological phenotypes: hereditary nonspherecytary hemolytic anemia, acute drug-induced hemolytic anemia, asymptomatic gene carrying and, selected by us disease with few symptoms. As a whole, among the revealed in the population studies, and also verified in clinic of the persons with deficiency of erythrocyte G6PD there were marked different pathological phenotypes: hereditary nonspherecytary hemolytic anemia, acute drug-induced hemolytic anemia, asymptomatic gene carrying and, selected by us disease with few symptoms.
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ISSN:1019-5297