HIV-1 genetic variants in the Asian part of Russia: a study (2005-2010)

The HIV-1 genetic variants circulated in the Asian part of the Russian Federation in 2005-2010 were studied. The samples of HIV-1 (427 in total) were collected in Khabarovsk, Magadan, Kurgan, Krasnoyarsk, Noyabr'sk, Yakutsk, Altay, and Tyva. Sequencing of some genome regions followed by the phy...

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Bibliographic Details
Published inVoprosy virusologiĭ Vol. 58; no. 4; p. 28
Main Authors Kazennova, E V, Vasil'ev, A V, Lapovok, I A, Grishechkin, A E, Laga, V Iu, Salamov, G G, Tumanov, A S, Parygina, O A, Ruzaeva, L A, Grezina, L A, Serkina, T P, Kaufman, O A, Oorzhak, N D, Lukashov, V V, Bobkova, M R
Format Journal Article
LanguageRussian
Published Russia (Federation) 01.07.2013
Subjects
Female
HIV Infections - epidemiology
HIV Infections - genetics
HIV-1 - genetics
Humans
Male
Phylogeny
Polymorphism, Genetic
Retrospective Studies
Siberia - epidemiology
Siberia
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Summary:The HIV-1 genetic variants circulated in the Asian part of the Russian Federation in 2005-2010 were studied. The samples of HIV-1 (427 in total) were collected in Khabarovsk, Magadan, Kurgan, Krasnoyarsk, Noyabr'sk, Yakutsk, Altay, and Tyva. Sequencing of some genome regions followed by the phylogenetic analysis or specific Internet resource sampling were used as the main methods of the HIV subtyping. The domination of the IDU-A HIV-1 genetic variant typical of HIV-infection epidemic in Russia was shown in all regions tested in 2005-2010. This variant prevailed both in IDUs and heterosexuals. In addition to IDU-A, some other HIV-1 genetic variants were found among them: subtype B and recombinant CRF03_AB. The HIV-1 genetic polymorphism in Russia was found to be low. An increase in the genetic distance among studied de novo samples was noted in the Asian part of Russia in 2005-2010 (26-68%) as compared to the European variants in 1996-1999 (10%).
ISSN:0507-4088