The study of telomere length in patients with Parkinson's disease

Telomeres which are formed by double-strand breaks and DNA under replication, cause cell cycle arrest resulting in cellular senescence and apoptosis. The erosion of telomeres is an important mechanism for regulating the aging process by limiting cell proliferation. Over the last decade, many investi...

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Published inZhurnal nevrologii i psikhiatrii imeni S.S. Korsakova Vol. 114; no. 8; p. 58
Main Authors Koliada, A K, Vaĭserman, A M, Krasnenkov, D S, Karaban', I N
Format Journal Article
LanguageRussian
Published Russia (Federation) 2014
Subjects
Aged
Biomarkers
DNA Breaks
Female
Humans
Leukocytes
Male
Middle Aged
Mouth Mucosa
Oxidative Stress - genetics
Parkinson Disease - pathology
Telomere - genetics
Telomere Homeostasis
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Summary:Telomeres which are formed by double-strand breaks and DNA under replication, cause cell cycle arrest resulting in cellular senescence and apoptosis. The erosion of telomeres is an important mechanism for regulating the aging process by limiting cell proliferation. Over the last decade, many investigations in the field of telomeric biology showed that telomeric DNA and telomeric proteins are involved in the pathogenesis of some human diseases. The aim of the study was to compare telomere length in patients with Parkinson's disease (PD). Telomere length was measured in buccal epithelial cells and leukocytes in PD patients and controls. The length of telomeres in cells of buccal epithelium was shorter in patients with PD than in the control group. In blood cells, telomere length did not differ. It is suggested that shortening of telomeres in buccal epithelial cells may be due to oxidative stress and, hence, it can be used as a marker for the early stages of disease.
ISSN:1997-7298