Establishment and Application of HPA1-6, 15 Platelet Donor Bank in Beijing Area

To establise the bank of platelet donors with the human platelet antigen (HPA) 1-6, 15 genes so as to provide the HPA-matched platelets for the patients. The HPA genotyping of platelets donors and patients with platelet antibody positive confirmed by sercening was performed by using the SSP-PCR; the...

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Published inZhongguo shi yan xue ye xue za zhi Vol. 28; no. 1; p. 296
Main Authors Wang, Xiao-Wei, Shao, Chun-Yan, Zhang, Jing, Reng, Ling-Ling, Zhuo, Hai-Long, Luo, Qun
Format Journal Article
LanguageChinese
Published China 01.02.2020
Subjects
Antigens, Human Platelet
Blood Donors
Blood Platelets
Gene Frequency
Genotype
Humans
Polymorphism, Genetic
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Summary:To establise the bank of platelet donors with the human platelet antigen (HPA) 1-6, 15 genes so as to provide the HPA-matched platelets for the patients. The HPA genotyping of platelets donors and patients with platelet antibody positive confirmed by sercening was performed by using the SSP-PCR; the efficacy of transfusing the HPA-matched platelets for 37 cases platelet antibody positive was analyzed. The most common genotype in platelet donors were HPA-1a/1a-2a/2a-3a/3b-4a/4a-5a/5a-6a/6a-15a/15b, followed by HPA-1a/1a-2a/2a-3a/3a-4a/4a-5a/5a-6a/6a-15a/15b; the most common genotype in 53 cases of platelet antibody positive confirened by screening were HPA-1a/1a-2a/2a-3a/3b-4a/4a-5a/5a-6a/6a-15a/15b. Among 37 patients with platelet antibody positive confirened by screeming, 28 showed that the transfusion of HPA-matched platelets was effective with statistically significant difference in comparison with random transfusion group. The HPA-3, HPA-15 were the main factors leading to polymorphisms. HPA-3 and HPA-15
ISSN:1009-2137
DOI:10.19746/j.cnki.issn.1009-2137.2020.01.049