HIV genetic subtypes and comparison of the first CD(4)(+)T cell counts in newly diagnosed HIV infected patients in Liuzhou, 1998-2012

• Published in: Zhōnghuá liúxíngbìng zázhì Vol. 40; no. 5; p. 580
• Main Authors: Cao, Z Q, Yang, W M, Zhu, Q Y, Lan, G H, Shen, Z Y, Liang, S S, Li, J J, Chen, H H, Feng, Y, He, X, Liao, L J, Xing, H, Ruan, Y H, Shao, Y M
• Format: Journal Article
• Language: Chinese
• Published: China 10.05.2019
• Subjects: Cell Count; China - epidemiology; DNA, Viral - genetics; Genotype; HIV Infections - blood; HIV Infections - diagnosis; HIV Infections - epidemiology; HIV Infections - virology; HIV-1 - classification; HIV-1 - genetics; HIV-1 - isolation & purification; Humans; Phylogeny; Polymerase Chain Reaction; RNA, Viral - isolation & purification; Sequence Analysis, DNA; T-Lymphocytes; China; HIV-1; CD(+)T cell counts; Genetic subtypes
• ISSN: 0254-6450
• DOI: 10.3760/cma.j.issn.0254-6450.2019.05.017

To analyze the change trend of HIV genetic subtypes and compare the first CD(4)(+)T cell counts of newly diagnosed HIV infected patients in Liuzhou from 1998 to 2012, and provide a reference for AIDS prevention and control. Newly diagnosed HIV-infected patients from 1998 to 2012 in Liuzhou were selected through national HIV/ADIS comprehensive response information management system. Their plasma samples were used for RNA gene extraction, amplification, sequencing and genotyping. Coharan-Armitage trend test was used to analyze the ratio trend of genetic subtypes and phylogenetic clusters of HIV and Wilcoxon Rank Sum Test was used to compare the first CD(4)(+)T cell counts (CD(4)) of the different subtype HIV infected patients. A total of 1 877 newly diagnosed HIV infected patients were included in the study. From 1998 to 2012, the proportions of CRF01_AE and CRF01_AE (Cluster 1) increased from 78.4% (76/97) to 91.5% (1 441/1 574), from 63.9% (62/97) to 74.0% (1 164/1 574), and the proportion of CRF07_BC decreas