Recognition study of double strand DNA with hairpin oligopolyamide

Selective recognition of double strands DNA(ds DNA) has been a research hot spot in molecular biology and biomedicine for a couple decades. Based on the selective interaction between natural nucleic acid/synthetic molecular ligands and ds DNA, gene diagnosis, gene therapy and gene editing would be r...

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Published inSheng wu yi xue gong cheng xue za zhi Vol. 34; no. 1; pp. 134 - 139
Main Authors Li, Wenjia, Shi, Huanhuan, Dong, Bo, Liu, Zhengchun
Format Journal Article
LanguageChinese
Published China 01.02.2017
Subjects
Base Sequence
DNA - chemistry
Ligands
Nucleic Acid Conformation
Nylons - chemistry
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Summary:Selective recognition of double strands DNA(ds DNA) has been a research hot spot in molecular biology and biomedicine for a couple decades. Based on the selective interaction between natural nucleic acid/synthetic molecular ligands and ds DNA, gene diagnosis, gene therapy and gene editing would be realized. Hairpin oligopolyamide is a molecular ligand with excellent cellular permeability and nucleases-resistance which can target ds DNA sequence with high affinity and specificity at minor groove. This paper reviews the binding properties and biomedical applications of hairpin oligopolyamide targeting ds DNA, which provide references for further design and application of hairpin oligopolyamide.
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ISSN:1001-5515