Relationship between lipid metabolism molecules in plasma and carotid atheroscle-rotic plaques, traditional cardiovascular risk factors, and dietary factors

• Published in: Beijing da xue xue bao. Journal of Peking University. Yi xue ban Vol. 56; no. 4; p. 722
• Main Authors: He, Jing, Fang, Zhongze, Yang, Ying, Liu, Jing, Ma, Wenyao, Huo, Yong, Gao, Wei, Wu, Yangfeng, Xie, Gaoqiang
• Format: Journal Article
• Language: Chinese
• Published: China 18.08.2024
• Subjects: Aged; Cardiovascular Diseases - blood; Cardiovascular Diseases - etiology; Carotid Artery Diseases - blood; Ceramides - blood; Ceramides - metabolism; Diet; Female; Follow-Up Studies; Heart Disease Risk Factors; Humans; Lipid Metabolism; Lipids - blood; Male; Middle Aged; Plaque, Atherosclerotic - blood; Risk Factors; Sphingomyelins - blood; Lipid metabolism molecules; Correlation analysis; Risk factors; Atherosclerosis
• ISSN: 1671-167X

To explore the relationship between lipid metabolism molecules in plasma and carotid atherosclerotic plaques, traditional cardiovascular risk factors and possible dietary related factors. Firstly, among 1 312 community people from those who participated in a 10-year follow-up study of subclinical atherosclerosis cohort in Shijingshan District, Beijing, 85 individuals with 2 or more carotid soft plaques or mixed plaques and 89 healthy individuals without plaques were selected according to the inclusive and the exclusive criteria (< 70 years, not having clinical cardiovascular disease and other diseases, etc.). Secondly, 10 cases and 10 controls were randomly selected in the above 85 and 89 individuals respectively. Carotid plaques were detected using GE Vivid i Ultrasound Machine with 8L detector. Lipid metabolism molecules were detected by high performance liquid chromatography-mass spectrometry. The detection indexes included 113 lipid metabolism molecules. Traditional cardiovascular risk factors were collec