Introduction to novel vaccine adjuvants and their role in influenza vaccination

New vaccine approaches based on subunit vaccines and on highly purified recombinant proteins use adjuvants to compensate for the loss of immunostimulatory components that are naturally present in whole cell vaccines. The development of adjuvanted influenza vaccines comprising squalene emulsion adjuv...

Full description

Saved in:
Bibliographic Details
Published inAnnales pharmaceutiques françaises Vol. 71; no. 2; p. 104
Main Author Haensler, J
Format Journal Article
LanguageFrench
Published France 01.03.2013
Subjects
Adjuvants, Immunologic
Humans
Influenza A Virus, H5N1 Subtype - immunology
Influenza Vaccines - administration & dosage
Influenza, Human - prevention & control
Vaccination
Online AccessGet more information

Cover

More Information
Summary:New vaccine approaches based on subunit vaccines and on highly purified recombinant proteins use adjuvants to compensate for the loss of immunostimulatory components that are naturally present in whole cell vaccines. The development of adjuvanted influenza vaccines comprising squalene emulsion adjuvants effective against pandemic influenza strains highlights the contribution of novel adjuvants in increasing vaccine coverage by augmenting protection rates and by affording cross-strain protection and antigen dose-sparing. Nevertheless, the development of new adjuvants remains challenging in terms of quality and safety assurance and in terms of clinical and industrial development costs.
ISSN:0003-4509
DOI:10.1016/j.pharma.2013.01.003