The application value of shear wave dispersion and shear wave elastography combined with serological indicators in the evaluation of liver fibrosis

• Published in: Zhong hua yi xue za zhi Vol. 103; no. 29; p. 2246
• Main Authors: Li, X X, Cheng, G W, Liang, J, Huang, C, Qiu, L P, Ding, H
• Format: Journal Article
• Language: Chinese
• Published: China 08.08.2023
• ISSN: 0376-2491
• DOI: 10.3760/cma.j.cn112137-20221213-02641

To explore the application value of shear wave dispersion (SWD) and shear wave elastography (SWE) combined with serological indicators in the evaluation of liver fibrosis. A total of 219 patients with liver disorders who underwent liver biopsy were prospectively collected in Huashan Hospital, Fudan University from January 2021 to September 2022, including 130 males and 89 females, aged from 18 to 76 (42±12) years. All patients underwent SWD and SWE examinations before liver biopsy. Serological indicators including alanine aminotransferase(ALT), aspartate aminotransferase(AST), alkaline phosphatase(ALP)) and γ-glutamyl transpeptadase (GGT) were also collected. Based on pathological diagnosis of liver fibrosis stage (from S0 to S4), the distribution of dispersion slope and liver elastic modulus at different fibrosis stages were analyzed in all patients. All patients were divided 7: 3 into training set (156 cases) and validation set (63 cases) in chronological order. In training set, factors influencing liver fi