Respiratory and cardiovascular responses to hypoxia under activation or blockade inhibitory transmission

• Published in: Patologicheskaia fiziologiia i eksperimental'naia terapiia no. 2; p. 32
• Main Authors: Sanotskaya, N V, Matsievskii, D D, Lebedeva, M A
• Format: Journal Article
• Language: Russian
• Published: Russia (Federation) 01.04.2013
• Subjects: Aminophylline - administration & dosage; Aminophylline - pharmacology; Animals; Blood Pressure - drug effects; GABA Antagonists - administration & dosage; GABA Antagonists - pharmacology; Hemodynamics - drug effects; Hydroxybutyrates - pharmacology; Hypoxia - physiopathology; Injections, Intravenous; Male; Picrotoxin - administration & dosage; Picrotoxin - pharmacology; Pulmonary Ventilation - drug effects; Purinergic P1 Receptor Antagonists - administration & dosage; Purinergic P1 Receptor Antagonists - pharmacology; Rats; Respiratory Rate - drug effects; Synaptic Transmission - drug effects

Respiratory rhythm changes and hypoxic ventilatory responses were studied in anesthetized albino rats after administration GABA and adenosine receptor antagonists. Intracisternal microinjection of picrotoxin induced pathological periodic breathing. Picrotoxin intravenous administration caused the in...