Respiratory and cardiovascular responses to hypoxia under activation or blockade inhibitory transmission

Respiratory rhythm changes and hypoxic ventilatory responses were studied in anesthetized albino rats after administration GABA and adenosine receptor antagonists. Intracisternal microinjection of picrotoxin induced pathological periodic breathing. Picrotoxin intravenous administration caused the in...

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Bibliographic Details
Published inPatologicheskaia fiziologiia i eksperimental'naia terapiia no. 2; p. 32
Main Authors Sanotskaya, N V, Matsievskii, D D, Lebedeva, M A
Format Journal Article
LanguageRussian
Published Russia (Federation) 01.04.2013
Subjects
Aminophylline - administration & dosage
Aminophylline - pharmacology
Animals
Blood Pressure - drug effects
GABA Antagonists - administration & dosage
GABA Antagonists - pharmacology
Hemodynamics - drug effects
Hydroxybutyrates - pharmacology
Hypoxia - physiopathology
Injections, Intravenous
Male
Picrotoxin - administration & dosage
Picrotoxin - pharmacology
Pulmonary Ventilation - drug effects
Purinergic P1 Receptor Antagonists - administration & dosage
Purinergic P1 Receptor Antagonists - pharmacology
Rats
Respiratory Rate - drug effects
Synaptic Transmission - drug effects
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Summary:Respiratory rhythm changes and hypoxic ventilatory responses were studied in anesthetized albino rats after administration GABA and adenosine receptor antagonists. Intracisternal microinjection of picrotoxin induced pathological periodic breathing. Picrotoxin intravenous administration caused the increase of individual resistance to acute hypoxia. Aminophylline administration exerted the opposite effect. After pretreatment of hydroxybutyrate we observed different types of respiratory reactions to adenosine antagonist injection, which probably depended on the value of arterial blood pressure and cerebral hemodynamics.
ISSN:0031-2991