Cell engineering in nephrology: The current state and prospectives from the point of view of military medicine

• Published in: Voenno-medicinskij ̆zurnal Vol. 336; no. 9; p. 55
• Main Authors: Bel'skih, A N, Golota, A S, Krassii, A B, Nagibovich, O A
• Format: Journal Article
• Language: Russian
• Published: Russia (Federation) 01.09.2015
• Subjects: Acute Kidney Injury - therapy; Cell Engineering - methods; Cell Engineering - trends; Clinical Trials as Topic; Early Termination of Clinical Trials; Humans; Mesenchymal Stem Cell Transplantation - adverse effects; Mesenchymal Stem Cell Transplantation - methods; Military Medicine - methods; Military Medicine - trends; Nephrology - methods; Nephrology - trends; Tissue Engineering - methods; Tissue Engineering - trends
• ISSN: 0026-9050

This article is dedicated to the current state and prospectives of cell engineering in nephrology from the point of view of military medicine. The review is based on publications from January 1, 2014, to June 1, 2015, and consists of two parts. In the first part the main directions of the cell engineering development are mentioned. The only two clinical trials existed in the field are discussed in more detail. The second part deals with prospectives of cell engineering in nephrology. It is shown that currently this field is in the stage of preclinical experimentation. Of the two known clinical trials the first has failed to demonstrate any effectiveness of cell engineering, the second--will be completed only at the end of 2016. Also, the review notes an extraordinary cost of cell engineering experiments in nephrology. The analysis of publications allows to come to a conclusion that the future progress in prevention and treatment of acute kidney injury could go not in the direction of cell engineering but rather non-cell technologies. One of. the practical consequence of such a conclusion is a necessity to continue the improvement of already existing methods of machine renal replacement therapy.