Obstructive sleep apnea and stroke

More than half of the patients hospitalised with stroke suffer from sleep-disordered breathing and 5 - 10 % of patients with newly diagnosed obstructive sleep apnea (OSA) have a history of stroke. Epidemiological studies have shown that untreated OSA is an independent risk factor for stroke. Various...

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Bibliographic Details
Published inPneumologie (Stuttgart, Germany) Vol. 66; no. 8; p. 476
Main Authors Dumitrascu, R, Tiede, H, Rosengarten, B, Schulz, R
Format Journal Article
LanguageGerman
Published Germany 01.08.2012
Subjects
Evidence-Based Medicine
Humans
Sleep Apnea, Obstructive - complications
Sleep Apnea, Obstructive - diagnosis
Sleep Apnea, Obstructive - therapy
Stroke - diagnosis
Stroke - etiology
Stroke - therapy
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Summary:More than half of the patients hospitalised with stroke suffer from sleep-disordered breathing and 5 - 10 % of patients with newly diagnosed obstructive sleep apnea (OSA) have a history of stroke. Epidemiological studies have shown that untreated OSA is an independent risk factor for stroke. Various pathophysiological mechanisms may contribute to the development of stroke in these patients (i. e., OSA-associated arterial hypertension, atherosclerosis, atrial fibrillation, paradoxical embolism through a patent foramen ovale and disturbed cerebrovascular reactivity). Co-existent OSA has a negative impact on both the recovery of neurological functions and the survival of patients with stroke. On the other hand, CPAP therapy has beneficial effects on the incidence and recurrence of stroke in OSA and also on the clinical outcome of those patients who are victims of stroke.
ISSN:1438-8790
DOI:10.1055/s-0032-1309966