Association of allelic polymorphisms of genes matrix Gla-protein system with ischemic atherothrombotic stroke

• Published in: Fiziolohichnyi zhurnal (Kiev, Ukraine : 1994) Vol. 61; no. 1; pp. 19 - 27
• Main Authors: Garbuzova, V Yu, Stroy, D A, Dosenko, V E, Dubovyk, Ye I, Borodenko, A O, Shimko, K A, Obukhova, O A, Ataman, O V
• Format: Journal Article
• Language: Ukrainian
• Published: Ukraine 2015
• Subjects: Adult; Aged; Aged, 80 and over; Alleles; Bone Morphogenetic Protein 2 - genetics; Brain Ischemia - genetics; Brain Ischemia - pathology; Calcium-Binding Proteins - genetics; Case-Control Studies; Extracellular Matrix Proteins - genetics; Female; Gene Expression; Genotype; Humans; Intracranial Thrombosis - genetics; Intracranial Thrombosis - pathology; Male; Matrix Gla Protein; Middle Aged; Models, Genetic; Multigene Family; Polymorphism, Single Nucleotide; Receptors, Calcitriol - genetics; Risk; Stroke - genetics; Stroke - pathology; Vitamin K Epoxide Reductases - genetics
• ISSN: 2522-9028

There are results of the determination of 10 polymorphisms of matrix Gla-protein system (gene MGP-T(-138)-->C (rs1800802), G(-7)-->A (rs1800801), Thr83-->Ala (rs4236), gene VDR-FokI (rs2228570), BsmI (rs1544410), ApaI (rs7975232), TaqI (rs731236), gene GGCX-Arg325-->Gln (rs699664), gene VKORS1-T(2255)-->C (rs2359612), gene BMP-2-Ser37-->Ala (rs2273073)) into 170 patients with ischemic atherothrombotic stroke (IATS) and 124 healthy individual is (control group). It is established that there is a connection between the IATS and polymorphic variants of genes MGP (G(-7)-->A) and VKORC1 (T(2255)-->C). The risk of IATS in carriers of minor allele A/A (G(-7)-->A polymorphism) in 2.6 times higher than in carriers of the major allele (G/A + G/G), and C/C genotype (T(2255)-->C polymorphism) in 2.2 times higher than the homozygotes of major allele. The coincidence of patients T/C and G/G, C/C and G/A genotypes, and A/A genotype (G(-7)-->A polymorphism) with any genotype T(2255)-->C polymorphism are increases the risk of IATS.