Biological roles of adenosine deaminase acting on RNA and their relationship with human diseases

RNA editing, especially A-to-I RNA editing, is a common post-transcriptional modification in mammals. Adenosine deaminase acting on RNA (ADAR) is a key protein for A-to-I editing, which converts the adenosine group of a double-stranded RNA to creatinine group by deaminating it, resulting in a change...

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Bibliographic Details
Published inZhong nan da xue xue bao. Journal of Central South University. Yi xue ban Vol. 43; no. 8; p. 904
Main Authors Chen, Kezhu, Ma, Ruze, Wang, Fang
Format Journal Article
LanguageChinese
Published China 28.08.2018
Subjects
Adenosine - metabolism
Adenosine Deaminase - physiology
Base Sequence
Creatinine - metabolism
Deamination
Disease - etiology
Humans
RNA Editing - physiology
RNA, Double-Stranded
RNA-Binding Proteins - physiology
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Summary:RNA editing, especially A-to-I RNA editing, is a common post-transcriptional modification in mammals. Adenosine deaminase acting on RNA (ADAR) is a key protein for A-to-I editing, which converts the adenosine group of a double-stranded RNA to creatinine group by deaminating it, resulting in a change of nucleotide sequence. There are 3 types of ADARs (ADAR1, ADAR2, ADAR3) that have been found in recent years. The abnormalities of ADARs are closely related to many human diseases such as viral infections, metabolic diseases, nervous system diseases, and tumors.
ISSN:1672-7347
DOI:10.11817/j.issn.1672-7347.2018.08.014