Gastrointestinal ALK-positive anaplastic large cell lymphoma: a clinicopathological analysis of five cases

• Published in: Zhonghua bing li xue za zhi Vol. 52; no. 8; p. 785
• Main Authors: Chen, L, Ke, Z Y, Yang, S J
• Format: Journal Article
• Language: Chinese
• Published: China 08.08.2023
• Subjects: Anaplastic Lymphoma Kinase; Female; Gastrointestinal Tract - pathology; Humans; Lymphoma, Large B-Cell, Diffuse - genetics; Lymphoma, Large-Cell, Anaplastic - pathology; Male; Receptor Protein-Tyrosine Kinases - genetics
• ISSN: 0529-5807
• DOI: 10.3760/cma.j.cn112151-20230509-00322

To investigate the clinicpathological characteristics of ALK-positive anaplastic large cell lymphoma (ALCL) of the gastrointestinal tract, and to discuss its diagnosis and differential diagnosis. Five cases of gastrointestinal ALK-positive ALCL diagnosed and treated in Xijing Hospital of the Fourth Military Medical University, between 2011 and 2019 were collected. There were three male and two female patients, aged 5-42 years (mean 25 years). These patients clinically presented with fever and night sweats, weight loss, abdominal pain, abdominal mass, ulcers, bleeding, or intestinal obstruction, and underwent surgical resection of the tumors or endoscopic biopsy. The clinical manifestations, auxiliary examinations, histopathological characteristics, immunophenotypes and genetic alterations were analyzed. In this cohort, one case was common type, two cases were monomorphic variant of common type, and two cases were small cell variant. The tumor cells in all cases expressed ALK, CD30, and one or more T lymphocyt